glomerulonephritis(GN)
this term suggests inflammatory conditions of the glomerulus, but there are several types of GN and inflammatory changes are not always present. in many cases immune complexes damage the glomerulli.these are formed when antigens combine either within the kidney or elsewhere in the body ,and they circulate in the blood.when immune complexes lodges in the walls of the glomeruli they often cause an inflammatory response that impairs glomerular function.other immune mechanisms are also implicated in GN.
classification of GN is complex and based on a number of features :the cause,immunological characteristics and finding on microscopy.microscopic distinction is based on:
the extent of damage:
diffuse:affecting all glomeruli
focal:affecting some glomeruli
appearence:
proliferative: increased number of the cells in the glomeruli .
membranous:thickening of the glomerular basement membrane.


April 10th, 2008 at 1:01 pm
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