Rickets and osteomalacia
Rickets occurs in children and osteomalacia in adults after ossification is complete.they are caused by deficiency of vitamin D which promotes calcification of bone and absorption of calcium in the small intestine
deficiency may be due to:
1)dietary deficiency of vitamin D
2)malabsorption,e.g.coelic disease or following gastrointestinal surgery
3)lack of exposure to sunlight,e.g.pigmented skin,housebound people
4)excessive loss of vitamin D or its precursors,e.g.in choronic renal failure,haemodialysis
5)drugs that result in breakdown of vitamin D,e.g.anticonvulsants,including phenytoin.
In rickets,osteoid is deposited but calcification is incomplete although growth of the epiphyseal cartilage continues,growth is stunied.the bones remain soft and those of the lower limbs become bowed by the weight of the body.
In oesteomalacia there is increased and abnormal turnover of bone.as in rickets,osteoid is not calcified and the bones become soft,bowed and prone to fractures.
February 25th, 2008 at 7:15 pm
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February 27th, 2008 at 1:30 pm
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